The outbreak of the SARS-COV-2 (2019-nCoV) is having a huge impact all around the world.
In order to better support the research of SARS-COV-2 (2019-nCoV). Elabscience® is stepping up the research and development and production of a series of important target related products of
SARS-COV-2 (2019-nCoV), including new coronavirus associated antigen, antibody, peptide, etc.
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor, and S2 contains basic elements needed for the membrane fusion.
The coronavirus N protein is abundantly produced within infected cells. N protein has multiple functions, including binding to viral RNA to form the ribonucleocapsid and has also been proposed to have roles in virus replication, transcription and translation.In host cells, N proteins have been shown to cause deregulation of the cell-cycle, inhibit the production of interferon, up-regulate the production of COX2, up-regulate the activity of AP1, and induce apoptosis in serum deprived cells-of all which may have possible pathological consequences.
ACE2 (Angiotensin Converting Enzyme 2) is the receptor of SARS-CoV-2 infected cells, and the infection process depends on the serine protease TMPRSS2. Blocking the interaction between S protein and ACE2 is an effective way to treat coronavirus infection.
Proteinase K is a kind of high activity proteinase of subtilisin, which is used to degrade proteins in biological samples. It can be used to digest various proteins, and it can be used in a variety of molecular biology, cell biology and other related experiments, such as genomic DNA extraction, enzyme digestion and removal, cell permeability and so on.
Proteinase K is mainly used for the production of nucleic acid extraction kit, especially for nucleic acid extraction from samples of nucleic acid diagnosis and detection in vitro diagnosis (IVD) industry.