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The Ubiquitin proteasome system (UPS) plays fundamental roles in cell physiology, from degradation of proteins to protein trafficking, autophagy, mitophagy and posttranslational modification. Nature encodes ~700 E3 ligases to manage UPS function. Future drugs will come from UPS, such as E3 ligases , PROTACs and molecular glues . LifeSensors has the largest biologically active E3 ligase library. Unlocking UPS/E3 ligase functions requires multi-purpose toolbox. LifeSensors has developed TUBE (Tandem Ubiquitin Binding Entities) technology we have established robust E3 ligase assays for every class of ubiquitination.
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TUBE embedded Microtiter Plate-based assays are optimized for screening, and are fully customizable with any E3 ligase.
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Plate Based Assays are designed to enrich and capture polyubiquitin chains allowing for study of any E3 ligase or substrate pairs. Detection via a substrate-specific antibody allows for specificity |
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Discover and Evaluate the Performance of PROTAC and Molecular Glues in Cells & Tissue
TUBE-embedded plate-based High-Throughput assays can be used to monitor ubiquitination directly in cells and tissue. Capture and detection of Ubiquitination using a specific antibody which lets you monitor and quantify Pan-selective , K48 , or K63 polyubiquitination .
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We Built It We Can Run It
LifeSensors has developed and engineered these products specifically to evaluate and study the Ubiquitin Proteasome System. Our team’s expertise and decades of experience in this field gives us cutting edge insight into this system. We offer additional tailor-made services and technology to help support your research, your discovery.
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