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MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
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• Over 100,000 bioactive molecules in stock
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• Target 10,000+ key proteins in 20+ signaling pathways
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• Quality reports (LC/MS, NMR and HPLC) for each product
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• Release more than 1,000 latest biochemicals per month
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• Data sheet with detailed biological information
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• High purity & competitive prices
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• Delivery within 24 hours
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CAS No.: 2245231-10-9
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Research Area: HIV Integrase/HIV-1 Infection
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An orally active allosteric HIV-1 integrase inhibitor (ALLINI) that targets LEDGF/p75 binding site.
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Inhibits the binding of integrase to the HIV-1 RNA genome, thereby interfering with viral maturation.
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Displays picomolar IC50 in human PBMCs with a >24,000 therapeutic index against HIV-1.
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Solubility: DMSO: 125 mg/mL (252.52 mM; Need ultrasonic)
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CAS No.: 1076235-04-5
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Research Area: CRM1/Apoptosis/Cancer
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A reversible and orally active CRM1 inhibitor with CRM1 degrading and antitumor activities.
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Inhibits CRM1-dependent nuclear export, inducing cancer cell cycle arrest and apoptosis.
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Can be used for cancer research in general, and multiple myeloma in particular.
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Solubility: DMSO: 100 mg/mL (238.19 mM; Need ultrasonic)
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CAS No.: 1370651-20-9
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Research Area: Anaplastic lymphoma kinase (ALK)/Cancer
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An orally active anaplastic lymphoma kinase (ALK) inhibitor with an IC50 of
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Binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants.
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Can be used for the study of ALK-driven cancers.
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Solubility: DMSO: 100 mg/mL (178.11 mM; Need ultrasonic)
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MCE Peptides
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Structural
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Product Name
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Description
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XQ2B
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A cyclopeptide cGAS inhibitor that specifically blocks the binding of dsDNA and cGAS.
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Ac-IEPD-CHO
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A granzyme B (Ki = 80 nM) and caspase-8 inhibitor.
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MCE Natural Products
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Hyaluronic acid is a type of polysaccharide. Modification of hyaluronic acid can be better applied in more fields.
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MCE Compound Library
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Provide professional compound library, serving cancer, immunity, metabolism and other fields of research.
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Product Name
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Description
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Amino Acid Metabolism Compound Library
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The 200+ compounds included in this library target various amino acid metabolic enzymes, which can be used for the study of amino acid metabolic pathways and related diseases with amino acid metabolic abnormalities.
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Protein Kinase Compound Library
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The 2,800+ compounds included in this library target common protein kinase targets such as ALK, VEGFR, EGFR, etc., and are suitable for the study of various diseases.
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Latest Publications Citing Use of MCE Products
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Nature.
2024 Jul;631(8021):635-644.
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Nature.
2024 Jul;631(8021):686-693.
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Science.
2024 Jun 21;384(6702):eade8520.
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Cell.
2024 Jul 25;187(15):3936-3952.e19.
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Cell.
2024 Aug 8;187(16):4305-4317.e18.
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Products are for research use only and are not intended for human use. We do not sell to patients.
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