MCE | 新型的生物活性抑制劑產品 (HIV、Apoptosis、Cancer)

MCE | 新型的生物活性抑制劑產品 (HIV、Apoptosis、Cancer)

2024.09.04

MedChemExpress - Master of Bioactive Molecules (Inhibitors. Screening Libraries. Proteins)

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

•  Over 100,000 bioactive molecules in stock

•  Target 10,000+ key proteins in 20+ signaling pathways

•  Quality reports (LC/MS, NMR and HPLC) for each product

•  Release more than 1,000 latest biochemicals per month

•  Data sheet with detailed biological information

•  High purity & competitive prices

•  Delivery within 24 hours

CAS No.: 2245231-10-9

Pirmitegravir

Research Area: HIV Integrase/HIV-1 Infection

Pirmitegravir structure

An orally active allosteric HIV-1 integrase inhibitor (ALLINI) that targets LEDGF/p75 binding site.

Inhibits the binding of integrase to the HIV-1 RNA genome, thereby interfering with viral maturation.

Displays picomolar IC50 in human PBMCs with a >24,000 therapeutic index against HIV-1.

Solubility: DMSO: 125 mg/mL (252.52 mM; Need ultrasonic)

CAS No.: 1076235-04-5

Felezonexor

Research Area: CRM1/Apoptosis/Cancer

Felezonexor structure

A reversible and orally active CRM1 inhibitor with CRM1 degrading and antitumor activities.

Inhibits CRM1-dependent nuclear export, inducing cancer cell cycle arrest and apoptosis.

Can be used for cancer research in general, and multiple myeloma in particular.

Solubility: DMSO: 100 mg/mL (238.19 mM; Need ultrasonic)

CAS No.: 1370651-20-9

Ensartinib

Research Area: Anaplastic lymphoma kinase (ALK)/Cancer

Ensartinib structure

An orally active anaplastic lymphoma kinase (ALK) inhibitor with an IC50 of

Binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants.

Can be used for the study of ALK-driven cancers.

Solubility: DMSO: 100 mg/mL (178.11 mM; Need ultrasonic)

MCE Peptides

Structural

Product Name

Description

XQ2B

A cyclopeptide cGAS inhibitor that specifically blocks the binding of dsDNA and cGAS.

Ac-IEPD-CHO

A granzyme B (Ki = 80 nM) and caspase-8 inhibitor.

MCE Natural Products

Hyaluronic acid is a type of polysaccharide. Modification of hyaluronic acid can be better applied in more fields.

Product Name

Description

Sodium Hyaluronate Hydroxypropyltrimonium Chloride

Having good moisturizing and ionic properties and can be used in the research of pharmaceutical and cosmetic fields.

Sodium Acetylated Hyaluronate

With anti-wrinkle and deep skin penetration properties, and can be used in skin aging research and cosmetic development.

Silylanization hyaluronate ester

With good moisturizing properties and biocompatibility, and can be used in cosmetic research.

Cross-linked sodium hyaluronate gel

Having good moisturizing properties, viscoelasticity and biocompatibility, and can be used in the development of auxiliary materials in arthritis and ophthalmic surgery.

Aldehyde Sodium Hyaluronate

With good moisturizing properties and biocompatibility, and can be used in the research of pharmaceutical and cosmetic fields.

MCE Compound Library

Provide professional compound library, serving cancer, immunity, metabolism and other fields of research.

Product Name

Description

Amino Acid Metabolism Compound Library

The 200+ compounds included in this library target various amino acid metabolic enzymes, which can be used for the study of amino acid metabolic pathways and related diseases with amino acid metabolic abnormalities.

Protein Kinase Compound Library

The 2,800+ compounds included in this library target common protein kinase targets such as ALK, VEGFR, EGFR, etc., and are suitable for the study of various diseases.

Latest Publications Citing Use of MCE Products

Covers of Recent Publications

Nature.
2024 Jul;631(8021):635-644.

Nature.
2024 Jul;631(8021):686-693.

Science.
2024 Jun 21;384(6702):eade8520.

Cell.
2024 Jul 25;187(15):3936-3952.e19.

Cell.
2024 Aug 8;187(16):4305-4317.e18.

Cell Signaling Pathway

MCE USA

Tel: 609-228-6898

E-mail: sales@MedChemExpress.com

Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

MCE Europe

Tel: +4686500910

E-mail: eu.sales@MedChemExpress.com

Address: Bergkällavägen 37C 192 79 Sollentuna SWEDEN

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Products are for research use only and are not intended for human use. We do not sell to patients.

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