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On April 11, 2025, the U.S. Food and Drug Administration (FDA) announced a
groundbreaking initiative to gradually phase out traditional animal testing in
drug safety evaluations, promoting laboratory-grown organoids and
organ-on-a-chip systems instead. Described as a paradigm shift in pharmaceutical
research, this innovative move is expected to significantly enhance testing
accuracy, reduce development timelines and costs, and foster more ethical
research practices.
This shift is driven by the unique advantages of organoid technology, which
addresses critical limitations of traditional animal models. |
Why Organoids? |
Improved Predictive Accuracy: Unlike animal models, organoids replicate
the heterogeneity, microenvironment, and genetic features of human tissues,
making them more reliable for evaluating drug responses and resistance. |
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Figure 1. Diverse applications of organoid technology[1]. |
Faster and Cost-Effective: Traditional PDX (patient-derived xenograft)
models
can take 6-8 months per drug cycle. Organoids are easier to culture, offer
higher success rates, and enable high-throughput drug screening. |
Ethical Research Practices: Supporting the 3Rs principles——Replacement,
Reduction, and Refinement – organoids pave the way for more humane, scalable
preclinical research. |
Explore MedChemExpress’s Premium
Organoid &
3D Cell Culture Tools |
15% OFF Limited-Time Offer! |
To support this scientific shift, MCE is offering an exclusive 15% discount on
our full range of organoid and 3D cell culture tools through May
31, 2025. |
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Featured Products |
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Classification |
Product Name |
Application |
Basement Membrane Matrix |
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Organoid culture, in
vitro angiogenesis model.
Organoid culture.
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Organoid Culture Kit |
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Formulated and tested
for efficient construction of human
small cell lung cancer organoid.
Formulated and tested for efficient construction of
mouse intestinal organoid.
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Recombinant Protein |
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A growth factor for
epithelial tissues; binding to EGF receptors,
induces hyperplasic changes.
Used for the generation of intestinal, liver,
thyroid, and brain organoids.
Regulate the proliferation, migration, and survival
of endothelial cells, during embryogenesis. Used for
the generation of vascular organoids.
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Reference:
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[1] Corrò C, et al. Am J Physiol Cell Physiol. 2020 Jul
1;319(1):C151-C165. |
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Products are for research use only and are not intended for human use. We do
not sell to patients.
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