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| MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括超過 40,000 種用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。 |
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CAS No.: 1515887-44-1
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Research Area: TNF Inhibitor/Inflammation
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A potent TNF Inhibitor, with a Kd value of 9 nM for human TNFα.
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Inhibits wild-type TNF but does not inhibit L57F TNF.
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Has the ability to disrupt a preformed hTNF/hTNFR1 complex.
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Solubility: DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)
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CAS No.: 2660250-10-0
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Research Area: EGFR Inhibitor/Non-Small Cell Lung Cancer (NSCLC)
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A selective and orally active fourth-generation EGFR inhibitor with a robust antitumor activity.
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Potently inhibits EGFR+/T790M and EGFR+/T790M/C797S resistant mutants that maintains activity against the sensitizing mutations, especially L858R.
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Used for the research of the resistant EGFR-driven NSCLC.
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Solubility: DMSO : 125 mg/mL (224.54 mM; ultrasonic and warming and heat to 60°C)
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CAS No.: 2729996-45-4
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Research Area: RAF Kinase Inhibitor/KRAS Mutant Cancers
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A highly selective and orally active type II pan-RAF inhibitor, with an anticancer effect.
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Shows synergistic activity in KRAS mutant A549 and HCT116 cancer cells in combination with the MEK inhibitor Cobimetinib.
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Solubility: DMSO : 50 mg/mL (109.77 mM; ultrasonic and warming and heat to 80°C)
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CAS No.: 2411819-82-2
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Research Area: HIV-1 Entry Antagonist/HIV-1 Infection
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A potent HIV-1 gp120 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses.
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Has potent antiviral activity and low cytotoxicity.
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Solubility: DMSO : 100 mg/mL (235.06 mM; Need ultrasonic)
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CAS No.: 951659-40-8
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Research Area: nAChR Agonist/Systemic Insecticide
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A systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests.
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Used as a butenolide insecticide, and shows efficient protection to crops.
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Solubility: DMSO : 100 mg/mL (346.40 mM; Need ultrasonic)
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MCE Human Metabolite / Nuclear Receptor 化合物庫
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Compound Library
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Description
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Human Metabolite Library
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超過4,000 多種人體代謝物，包括內源性代謝物和外源性代謝物；
涵蓋lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins等多種結構類型；
可以作為研究疾病與代謝之間關係的研究工具。 |
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Nuclear Receptor Compound Library
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超過500多種核受體抑製劑和活化劑，均對核受體具有明確的抑製或活化作用；
可以作為癌症、皮膚病和糖尿病相關的藥物研究的工具。 |
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核酸萃取與純化
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| MCE 核酸純化試劑盒可以有效純化genomic DNA/Viral DNA/RNA/Plasmid DNA，此產品運用核酸與二氧化矽纖維膜結合的原理，可有效分離genomic DNA/Viral DNA/RNA/Plasmid DNA。萃取過程包括製備裂解樣品、與膜結合、洗滌和洗脫。使用此產品純化的核酸可用於PCR、RT-PCR和qPCR等實驗應用。 |
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Cat. No
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Product
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Size
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Application
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HY-K1081
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Genomic DNA Mini Purification Kit
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50T
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Purification of genomic DNA
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HY-K1082
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Viral DNA/RNA Mini Purification Kit
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50T
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Purification of Viral DNA/RNA
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HY-K1083
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Plasmid DNA Maxi Purification Kit
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20T
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Purification of Plasmid DNA
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Latest Publications Citing Use of MCE Products
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Nature.
2022 Sep;609(7928):829-834.
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Cell.
2022 Sep 1;185(18):3356-3374.e22.
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Cancer Cell.
2022 Sep 12;40(9):1044-1059.e8.
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Cell Stem Cell.
2022 Sep 1;29(9):1366-1381.e9.
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