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| 亞旭所代理的MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。 |
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•超過 30,000 種生物活性分子化合物的庫存
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•超過針對 20 多種信號通路中的 500 多種關鍵目標蛋白的化合物
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•產品均附上品質報告書（LC/MS、NMR 和 HPLC）
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•每月發布超過500 種最新的產品
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•提供詳細Datasheet的資訊
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•高純度和有競爭力的價格
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• 快速到貨
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新產品列表
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Research Area: Akt Inhibitor/Multiple Myeloma
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Potent, selective, orally active allosteric Akt inhibitor (IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively).
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Triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition.
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Induces apoptosis and autophagy.
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Solubility: DMSO : 62.5 mg/mL (135.59 mM; ultrasonic and warming and heat to 60°C)
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CAS No.: 2230044-57-0
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Research Area: p53 Mutation Y220C Stabilizer/Gastric Cancer
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An aminobenzothiazole derivative and a potent oncogenic p53 mutation Y220C stabilizer.
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Binds tightly to the Y220C pocket and stabilizes p53-Y220C.
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Shows anticancer activity in p53-Y220C cell lines.
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Solubility: DMSO : 25 mg/mL (54.67 mM; Need ultrasonic)
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CAS No.: 1069858-99-6
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Research Area: Protein Disulfide Isomerase Inhibitor/Arterial Thrombosis-Related Diseases
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Specific inhibitor of protein disulfide isomerase (PDI) with an IC50 of 250 nM.
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Inhibits thrombus formation in a mouse laser injury model.
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Solubility: DMSO : 100 mg/mL (239.27 mM; Need ultrasonic)
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CAS No.: 736183-35-0
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Research Area: Prostanoid EP4 Receptor Antagonist/Migraine Headache
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Potent and selective prostanoid EP4 receptor antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6).
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Competitively antagonizes PGE2-induced vasodilatation of human middle cerebral (pKB=7.8) and meningeal (pKB=7.6) arteries.
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Solubility: DMSO : 250 mg/mL (507.57 mM; Need ultrasonic)
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CAS No.: 195199-95-2
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Research Area: 5-HT7 Receptor Antagonist/Cancer and Neurological Disease
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Potent and selective 5-HT7 receptor antagonist with high affinity (pKi=7.5).
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Antagonizes surmountably 5-CT-stimulated adenylyl cyclase activity and reduces proliferation of HuH-7 and HepG2 cells, and also down regulates β-catenin.
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Solubility: DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)
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CAS No.: 1636894-46-6
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Research Area: HDAC6 Inhibitor/Melanoma and Colorectal Cancer
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Potent and selective HDAC6 inhibitor, with an IC50 of 2.5 nM.
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Shows antitumor efficacy and immune modulatory effects in preclinical models.
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Solubility: DMSO : 66.67 mg/mL (206.84 mM; Need ultrasonic)
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SYBR Green qPCR Master Mix (Universal)
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MCE SYBR Green qPCR Master Mix (Universal) is compatible with all qPCR instruments. 2× ready-to-use formulations which consist of antibody-mediated hot start polymerase, MgCl2, dNTPs and a proprietary reaction buffer, produce optimal results in qPCR experiments.
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Comparison of chemical and antibody hot-start technologies
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Hot-start technology
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Introduction
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Features
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Chemical-mediated
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Polymerases are covalently linked with chemical groups to block enzyme activity at room temperature. As temperature rises, chemical bonds break and enzyme activity is restored.
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Long activation time;
Full activation of the enzyme is often not possible;
Free of animal-origin components.
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Antibody-mediated
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Polymerases are bound by antibodies at their active sites to block enzyme activity at room temperature. As temperature rises, antibodies get denatured and enzyme activity is restored.
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Short activation time;
Full enzyme activity is restored after activation;
Antibodies may be of animal origin and may cause contamination of the PCR sample.
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Anti-infection Related Libraries
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| COVID-19 目前還在全球蔓延，給社會帶來沉重負擔。此外由病毒、細菌、真菌和寄生蟲等病原體引起的感染對人們的健康造成嚴重威脅。而對抗菌藥物的耐藥性已成為全球發病率和死亡率的主要來源。 因此，開發新型有效的抗感染疾病藥物迫在眉睫。
亞旭代理的MCE 提供超過 1800 種抗感染疾病的化合物，這些化合物已認證具有抗菌、抗病毒、抗真菌和抗寄生蟲活性，可用於抗感染藥物篩选和機制的研究。 |
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Catalog No
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Anti-infection libraries
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Number of compounds
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HY-L002
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Anti-Infection Compound Library
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1800+
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HY-L027
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Antiviral Compound Library
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600+
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HY-L049
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Antibacterial Compound Library
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800+
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HY-L067
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Antibiotics Library
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500+
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HY-L048
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Antifungal Compound Library
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200+
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HY-L082
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Antiparasitic Compound Library
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300+
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HY-L073
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Anti-Hepatitis C Virus Compound Library
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200+
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HY-L052
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Anti-COVID-19 Compound Library
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1500+
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近期文獻引用 MCE 產品
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Science. 2021 Oct;
374(6563):eabf3067.
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Immunity. 2021 Oct 12;
54(10):2354-2371.e8.
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Cancer Cell. 2021 Oct 11;
39(10):1361-1374.e9.
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Cell Metab. 2021 Oct 5;
33(10):2040-2058.e10.
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更多產品資訊請洽亞旭或MCE官網
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