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| MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括超過 50,000 種用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。 |
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Research Area: Kv1.3 Inhibitor/Inflammatory Diseases
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A specific Kv1.3 potassium channel peptide inhibitor.
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Used in the study of autoimmune diseases such as multiple sclerosis.
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Inhibits delayed-type hypersensitivity, suppresses the motility and activation of Tem cells in vivo.
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CAS No.: 2171511-58-1
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Research Area: EGFR-MET Antibody/Immune Anticancer
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Inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes.
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Induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.
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Exhibits anti-cancer activity in EGFR exon 20 insertion-driven NSCLC models.
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CAS No.: 66529-17-7
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Research Area: α2-Adrenoceptor Antagonist/Blood Pressure/Blood Glucose
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A potent α2-adrenoceptor antagonist.
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Stimulates insulin release in vitro.
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Increases blood pressure and reduces blood glucose levels in vivo.
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Solubility: DMSO : 162.5 mg/mL (ultrasonic)
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CAS No.: 2523016-96-6
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Research Area: PROTAC PARP1 Degrader/Cancer
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A highly potent and specific PROTAC degrader of PARP1.
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Exhibits significant antitumor activity in breast cancer models.
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Solubility: DMSO : 200 mg/mL (228.06 mM; Need ultrasonic)
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CAS No.: 2360853-16-1
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Research Area: PARP14 Inhibitor/Inflammatory Diseases
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A selective PARP14 inhibitor with an IC50 value of 4 nM.
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Inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cells.
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Used in research of inflammation. Improves steroid-resistant asthma in vivo.
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Solubility: DMSO : 12.5 mg/mL (27.81 mM; ultrasonic and warming and heat to 80°C)
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MCE Heterocyclic 化合物庫
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| Heterocyclic化合物在生物學中算是一種很常見的化合物，從酶的輔助因子到氨基酸、蛋白質的廣泛結構都會有。另一方面，Heterocycles在開發階段藥物及核准藥物中也是常見的結構單元。此外，Heterocycles已被認為是醫學化學中的關鍵結構，而且經常出現在大部分生物分子中，例如: 維生素、天然化合物和多種生物活性化合物。
MCE 提供超過 5,500 多種Heterocyclic化合物的化合物庫，可用於高通量和高內涵的藥物篩選。對於藥物發現和開發來說，MCE的雜環化合物庫可以說是好用且重要的工具。 |
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MCE Isotope-labeled Compounds
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MCE Glycan
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| Glycan是由許多具有共價鍵的單醣分子組成的複雜聚合物，而且是細胞“身份”的重要標記物。在細胞表面有許多數量和多樣的Glycan修飾，有助於細胞之間或與外部環境的交流。一些研究顯示，Glycan在癌症、自身免疫疾病..等等許多重大疾病中有著關鍵作用。 |
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Product Name
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Cas No.
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Description
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Maltopentaose
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34620-76-3
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The shortest chain oligosaccharide that can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin.
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Heparan Sulfate
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9050-30-0
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Existing as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
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Stachyose tetrahydrate
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10094-58-3
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Preventing indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine.
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Laminaran
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9008-22-4
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A typical ligand for Dectin-1, has potent immunomodulating, radioprotective, and anticancer activities.
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最新文獻引用MCE產品
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Nature.
2023 Jan;613(7942):187-194.
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Nature.
2022 Dec;612(7941):725-731.
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Nature.
2023 Jan;613(7942):145-152.
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Nature.
2023 Jan;613(7942):120-129.
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Immunity.
2023 Jan 10;56(1):180-192.e11.
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