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MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
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CAS No.: 2770263-77-7
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Target/Research Area: PROTAC/HDAC/Cancer
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A selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells.
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Effectively induces HDAC8 protein degradation and inhibits cancer cell growth.
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Hampers DNA damage repair in cancer cells.
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Solubility: DMSO: 116.67 mg/mL (165.09 mM; Need ultrasonic)
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CAS No.: 1549811-36-0
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Target/Research Area: Protein Arginine Deiminase/Multiple Myeloma
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A selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM.
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Blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation.
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Can be used in the study of multiple myeloma.
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Solubility: 35 mg/mL (68.76 mM; Need ultrasonic)
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CAS No.: 2240202-02-0
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Target/Research Area: Neuromedin U Receptor/Neurological Disease
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A selective hexapeptidic neuromedin U receptor 2 (NMUR2) agonist with an EC50 value of 2.2 nM.
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Intranasal administration suppresses appetite and prolactin secretion in mice.
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Solubility: H2O: 32 mg/mL (37.69 mM; Need ultrasonic)
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MedChemExpress Molecular Interaction Assay Service
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MedChemExpress offers a professional molecular interaction detection platform including Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), Isothermal Titration Calorimetry (ITC), Microscale Thermophoresis (MST) and Nano Differential Scanning Fluorimetry (nanoDSF). Coupled with professional services of virtual screening, protein expression and purification, we provide a one-stop solution for drug discovery!
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Method
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Key features
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Results
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Applicable
sample types
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SPR
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• Label-Free Detection
• Real-Time Monitoring
• High Sensitivity
• Low sample consumption
• High-Throughput Detection
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KD
Ka (Kon)
Kd (Koff)
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• Proteins
• DNA/RNA
• Lipids
• Polysaccharides
• Peptides
• Small molecules
• Cell Lysate
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MST
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• Low sample consumption
• Short measurement time
• Analysis in complex buffers
• No need for sample immobilization
• High sample compatibility
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KD
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BLI
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• Label-free detection
• Low sample consumption with high sensitivity
• Real-Time Monitoring
• Wide range of applications
• High-throughput detection
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KD
Ka (Kon)
Kd (Koff)
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ITC
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• No fluorescent labeling or
immobilization required for samples
• High sensitivity and precision
• Thermodynamic properties can be measured
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KD
n (stoichiometric ratio)
ΔH (enthalpy change)
ΔS (entropy change)
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nanoDSF
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• No fluorescent labeling or immobilization required for samples
• High throughput
• Low sample consumption
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Tm
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MedChemExpress Natural Products
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Sugars are the most abundant class of organic compounds that play many structural and biological roles in living organisms. Sugar molecules are actively involved in energy storage and transport, signaling, intercellular communication, pathogenesis, immune responses, and regulation of protein and lipid functions.
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Product Name
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Description
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Biflorin
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Monosaccharide; antibacterial, anti-tumor, anti-inflammatory and anti-mutational activities.
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Sarmentosin
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Monosaccharide; Nrf2 activator; inhibits the mTOR signaling pathway and induces autophagy-dependent apoptosis in human hepatocellular carcinoma cells.
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Stachyose hydrate
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Polysaccharides; enhances the growth and activity of beneficial bacteria, has hypoglycemic effects, may improve inflammation by regulating gut microbes.
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Rehmannioside A
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Polysaccharide; neuroprotectant; inhibitor of NF-κB and MAPK.
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Pectin
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Polysaccharide; can be used as a carrier for nanoparticle active molecules; adsorbent; broad-spectrum antimicrobial agent.
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MedChemExpress Compound Library
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Provide professional compound library, serving cancer, immunity, metabolism and other fields of research.
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Product Name
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Description
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Lactic Acid Metabolic Compound Library
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Contains 300+ compounds targeting lactate metabolic enzymes, which are of great value for studying lactate metabolic pathways and exploring its mechanism of action in diseases.
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Latest Publications Citing Use of MedChemExpress Products
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Nature.
2025 Jan;637(8045):402-411.
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Nature.
2025 Jan;637(8044):184-194.
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Science.
2024 Dec 13;386(6727):eado5561.
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Cell.
2025 Jan 9;188(1):157-174.e22.
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