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亞旭所代理的MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。
• 超過 30,000 種生物活性分子化合物的庫存
• 超過針對 20 多種信號通路中的 500 多種關鍵目標蛋白的化合物
• 產品均附上品質報告書（LC/MS、NMR 和 HPLC）
• 每月發布超過500 種最新的產品
• 提供詳細Datasheet的資訊
• 高純度和有競爭力的價格
• 快速到貨 |
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CAS No.: 2711006-67-4
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Research Area: PROTAC CRBN Degrader/Multiple Myeloma
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Potent and highly selective PROTAC CRBN degrader which is a CRBN-VHL compound (hetero-PROTAC).
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Induces ~80% CRBN degradation at 10 nM in MM1.S cells.
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Solubility: DMSO : 170 mg/mL (172.57 mM; Need ultrasonic)
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Research Area: DHODH Inhibitor/Malaria
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Potent antimalarial and orally active, selective Plasmodium DHODHs inhibitor.
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Shows inhibitory activity against P. falciparum DHODH (PfDHODH, IC50=95 nM), P. vivax DHODH (PvDHODH, IC50=52 nM) and Pf3D7 cells (EC50=12 nM), with no inhibition of the human enzyme.
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Solubility: DMSO : 100 mg/mL (226.83 mM; Need ultrasonic)
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CAS No.: 1312547-19-5
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Research Area: NS5A Inhibitor/HCV Infection
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Potent and orally active NS5A inhibitor of HCV replication, with EC50s of 2 to 24 pM in genotype 1 through 5 replicons.
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Selective for HCV and is not active against other DNA and RNA viruses.
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Effectively combined with other classes of direct-acting HCV antivirals, as well as IFN-α and Ribavirin.
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Solubility: DMSO : 50 mg/mL (56.49 mM; Need ultrasonic)
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Research Area: PDE2 Inhibitor/Depression
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Highly selective, orally active PDE2 inhibitor with an IC50 of 0.57 μM for PDE2A.
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Shows over 250-fold selectivity against other recombinant PDE family members.
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Has neuroprotective and antidepressant‐like effects.
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Solubility: DMSO : 62.5 mg/mL (164.28 mM; Need ultrasonic)
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CAS No.: 2097117-06-9
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Research Area: P2X7 Receptor Antagonist/Neuroinflammation and CNS Diseases
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Orally active, rodent-active, and CNS-penetrant P2X7 receptor antagonist (IC50s=12 and 2.4 nM for human and rat P2X7 receptor, respectively; Kis=22, 54, and 13 nM for mouse, human and rat P2X7 receptor, respectively).
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Has the potential for the research of CNS disease.
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Solubility: DMSO : 125 mg/mL (251.04 mM; Need ultrasonic)
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Apoptosis Detection Kit
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Kit
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Description
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Annexin V-FITC/PI Apoptosis Detection Kit
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MCE Annexin V-FITC/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis.
After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence (Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).
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Cell Cycle and Apoptosis Analysis Kit (PI staining)
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MCE Cell Cycle and Apoptosis Analysis Kit (PI staining) provides a convenient method to detect cell cycle and cell apoptosis.
The content of DNA is changed with the process of cell cycle. DNA can be stained by fluorescent dye, such as Propidium Iodide (PI), to measure its intensity by flow cytometry to monitor the cell cycle distribution in G1/S/G2/M phase as well as apoptosis cells with signals at sub-G1 region.
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黃酮類Flavonoids
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黃酮類化合物Flavonoids是指通過將兩個苯環（A環和B環）與三個中心碳連接而合成的一系列化合物。 之所以被稱為黃酮類化合物，是因為它們的結構中含有酮基，且顏色通常是黃色的。黃酮類化合物廣泛存在於自然界中， 大多與醣類結合形成植物中的flavonoid glycosides。 一般來說，黃酮類化合物可分為多個族群，例如：flavones、dihydroflavones、chalcone和isoflavones.
黃酮類化合物具有廣泛的活性，像是在自然界常見的黃酮類化合物-Rutin，具有抗氧化、抗發炎和抗病毒活性；而從Silybum marianum中萃取的Silymarin具有抗病毒和抗腫瘤作用。
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Cat. No.
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Drug Name
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Structure
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Description
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HY-N1860
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3-O-Methylquercetin
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Inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. Exhibits IC50s ranging from 1.6-86.9 μM for PDE isozymes (PDE1-5).
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HY-N6896
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Isoviolanthin
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Markedly inhibits TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Exhibits no cytotoxic effects on normal liver LO2 cells.
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HY-N7012
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7,3′,4′-Tri-O-methylluteolin
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Possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines.
Significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2.
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HY-N2412
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Irisolidone
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Shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM). Hepatoprotective activity.
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