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| 亞旭所代理的MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。 |
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• 超過 30,000 種生物活性分子化合物的庫存
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• 超過針對20多種信號通路中的500多種關鍵目標蛋白的化合物
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• 產品均附上品質報告書（LC/MS、NMR 和 HPLC）
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• 每月發布超過500 種最新的產品
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• 提供詳細Datasheet的資訊
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• 高純度和有競爭力的價格
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• 快速到貨
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CAS No.: 943609-66-3
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Research Area: Integrin/Inflammatory Bowel Diseases (IBD)
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A humanized IgG1 monoclonal antibody that targets the α4β7 integrin selectively.
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Restricts the recruitment of β7+ effector monocytes to the intestinal epithelium.
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Research Area: HOX/PBX/Leukemia
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A competitive antagonist of HOX/PBX interaction.
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Prevents HOX/PBX dimers from binding to DNA.
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Selectively inhibits cell proliferation and promotes apoptosis in cancer cells.
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Solubility: H2O : 50 mg/mL (18.15 mM; Need ultrasonic)
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CAS No.: 1582289-91-5
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Research Area: PAI-1/Glioma
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An orally active, BBB-penetrant PAI-1 inhibitor by inhibiting the phosphorylation of PI3K and AKT.
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Possesses potent anti-glioblastoma (GBM) activity and immunomodulatory effects.
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Significantly decreases PD-L1 expression in a dose-dependent manner.
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Solubility: DMSO : 100 mg/mL (244.22 mM; ultrasonic and warming and heat to 60°C)
H2O : 100 mg/mL (244.22 mM; Need ultrasonic)
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CAS No.: 2251806-70-7
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Research Area: Parkinson’s Disease
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A corticalpreferring catecholamine- and cognition-promoting agent.
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Has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function.
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Solubility: DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
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Research Area: PROTAC/Intestinal Tumor
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Highly potent and selective degrader of splicing factor 3B1 (SF3B1).
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Induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells.
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PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.
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Solubility: DMSO : 250 mg/mL (410.44 mM; Need ultrasonic)
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MCE Peptide Library/MCE Cyclic Peptide Library
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Library
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Description
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MCE Peptide Library
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超過600條Peptide，包括具有生物活性Peptide、氨基酸衍生物和Blocking Peptide
MCE Peptide Library可用於Peptide Library篩選、Peptide藥物研發、疫苗開發、標靶驗證、結構活性研究等 |
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MCE Cyclic Peptide Library
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超過50條Cyclic Peptide，例如Gramicidin、Cyclosporine A、Vancomycin等等
具有結合親和能力優良、靶點選擇性、低毒性等特點
MCE Cyclic Peptide Library 是藥物研發和 PPI 抑製劑篩選的強大工具。 |
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MCE Exosome相關檢測試劑
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| 外泌體Exosome是由30-150 nm大小所組成的小囊泡，內含有 RNA 和蛋白質，主要由培養中的各種細胞所分泌，此外也在血液、唾液、尿液和母乳等體液中大量存在。外泌體被認為是細胞間的信使，在特定細胞之間傳遞反應物或大分子訊號。
MCE 提供從細胞培養基、血漿、血清中分離和純化完整外泌體的試劑，可以與Exosome蛋白檢測試劑(CD63&TSG101）)作為搭配，適用於外泌體的分離與檢測完整流程。 |
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Cat. No
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Product
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Size
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Application
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HY-K1062
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Exosome Isolation and Purification Kit
(from cell culture media)
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20T
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Isolation of exosome
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HY-K1063
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Exosome Isolation and Purification Kit
(from plasma and serum)
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30T
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Isolation of exosome
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HY-K1064
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Exosome Protein Detection Kit
(CD63 & TSG101)
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5T
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Detection of exosome
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Latest Publications Citing Use of MCE Products
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Nature.
2022 May;605(7910):567-574.
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Nature.
2022 May;605(7911):747-753.
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Cell.
2022 May 11;S0092-8674(22)00526-8.
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Adv Mater.
2022 May;34(21):e2200517.
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