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| 亞旭所代理的MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括超過 40,000 種用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。 |
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CAS No.: 1443994-46-4
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Research Area: Smad7 ASO/Crohn’s Disease
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An orally active SMAD7 antisense oligonucleotide.
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Inhibits TGF-β1 pathways and alleviates Crohn’s disease.
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CAS No.: 1709886-74-7
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Research Area: Huntingtin Protein ASO/Huntington’s Disease
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A second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production.
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Used for the research of Huntington’s disease.
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CAS No.: 2743427-26-9
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Research Area: FAK Degrader
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A selective PROTAC degrader of focal adhesion kinase (FAK).
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Induces rapid and prolonged FAK degradation.
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Long-lasting effect on FAK levels and a marked PK/PD disconnect.
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Solubility: DMSO : 250 mg/mL (253.77 mM; Need ultrasonic)
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CAS No.: 71145-03-4
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Research Area: Calcium Channel Activator
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A specific L-type Ca2+ channel agonist.
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Increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel.
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Possesses positive inotropic, vasoconstrictive and behavioral effects.
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Solubility: DMSO : 83.33 mg/mL (233.88 mM; Need ultrasonic)
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Research Area: CDK/Breast Cancer/Eesophageal Squamous Cell Carcinoma
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An orally active and highly selective inhibitor of CDK4/6.
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Shows antitumor activity against breast cancer and esophageal squamous cell carcinoma.
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Exerts antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest.
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Solubility: DMSO : 5 mg/mL (10.35 mM; ultrasonic and warming and heat to 60°C)
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MCE EMA-Approved Drug Library/ FDA-Approved Anticancer Drug Library
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Natural products of microorganisms
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| 1928年，Alexandra Fleming發現了青黴素，開創了微生物藥物的新領域。 在接下來的幾十年裡，微生物天然產物的藥物開發一直是新藥研發領域的熱門選擇。 微生物產生的次級代謝產物具有多種生物活性，可用作抗癌藥、抗寄生蟲藥、抗發炎藥、免疫抑製劑等，對人體健康發揮著重要作用。 |
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Product Name
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Description
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Fusicoccin
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Stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth.
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Gliotoxin
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Inhibiting the phagocytosis of macrophages and the immune functions of other immune cells.
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Aflatoxin M1
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A major metabolite of Aflatoxin B1.
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Manumycin A
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Acting as a selective, competitive inhibitor of protein farnesyltransferase (FTase).
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Cercosporin
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A potent photosensitizer, PKC inhibitor.
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Latest Publications Citing Use of MCE Products
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Nature.
2022 Jul;607(7917):135-141.
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Nature.
2022 May;605(7910):567-574.
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Cell.
2022 Jun 23;185(13):2234-2247.e17.
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Immunity.
2022 Jul 7;S1074-7613(22)00280-1.
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