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MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。
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• 超過 40,000 種生物活性分子化合物的庫存
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• 超過針對20多種信號通路中的500多種關鍵目標蛋白的化合物
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• 產品均附上品質報告書（LC/MS、NMR 和 HPLC）
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• 每月發佈超過1000 種最新的產品
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• 提供詳細Datasheet的資訊
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• 高純度和有競爭力的價格
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• 快速到貨
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CAS No.: 2256084-03-2
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Research Area: Anti-PD-L1 Antibody/Non-small Cell Lung Cancer (NSCLC)
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A fully human, full length, anti-PD-L1 IgG4 monoclonal antibody (mAb).
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Used for the research of NSCLC, advanced solid tumours and lymphoma.
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Solution: 30 mg/mL
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CAS No.: 1818864-51-5
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Research Area: Drug-Linker Conjugates for ADC
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Consists a cleavable ADC linker (MC-VA-PABC) and a tubulin polymerization inhibitor MMAE.
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Inhibits cell division and anticancer activity.
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Used for the synthesis of antibody-drug conjugates (ADCs).
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DMSO: 100 mg/mL (81.27 mM; Need ultrasonic)
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CAS No.: 2055200-88-7
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Research Area: APJ Receptor Agonist/Heart Failure
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A potent, selective and orally active APJ receptor agonist with a Kd value of 0.3 nM.
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Has the potential for heart failure research.
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DMSO: 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
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CAS No.: 2756333-39-6
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Research Area: PARP1 Inhibitor/Brain Malignancies
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A selective and CNS penetrant PARP1 inhibitor that acts by inhibiting and trapping PARP1 at the sites of DNA single-strand breaks (SSBs).
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Used for primary and secondary brain malignancies research.
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DMSO: 22.22 mg/mL (51.86 mM; ultrasonic and adjust pH to 4 with HCl)
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CAS No.: 2254004-96-9
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Research Area: Nrf2 Activator/Parkinson’s Disease
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A potent Nrf2 Activator with anti-inflammatory activity.
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Upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2.
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Neuroprotective effect is mediated by Nrf2 activation and NLRP3 inflammasome inhibition.
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DMSO: 17.86 mg/mL (ultrasonic; warming; heat to 60°C)
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MCE Anti-Prostate Cancer Compound Library/ Anti-Pulmonary Fibrosis Compound Library/ Anti-Orthopoxvirus Compound Library
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Anti-His磁珠
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| MCE Anti-His Magnetic Beads 用在細菌、哺乳動物細胞以及其他表達系統所表達的特定 His tag蛋白進行免疫沉澱 (IP)。Anti-His Magnetic Beads具有高乘載His tag蛋白以及高特異性，也適合用在His tag蛋白的純化和免疫共沉澱 |
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Characteristics
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Composition
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Composition Mouse IgG monoclonal antibody covalently coupled to a blocked magnetic bead surface
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Bead Diameter
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2 μm
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Binding Capacity
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> 0.5 mg protein/mL of beads
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Application
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IP, Co-IP, Protein Purification
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Recommended Dose
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25 μL for per 500 μL cell lysates
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CEPT Cocktail
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| MCE CEPT Cocktail由 CET 小分子(Chroman 1、Emricasan、Trans-ISRIB)和Polyamine溶液所組成，可提高細胞存活率並促進遺傳穩定的hPSCs生長，此外也可以將幹細胞研究中的數個應用進行優化，包括常見的細胞繼代、多能和分化細胞的冷凍保存、胚狀體(EB)和類器官的形成等。 |
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Latest Publications Citing Use of MCE Products
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Cell.
2022 Aug 18;185(17):3124-3137.e15.
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Nature.
2022 Aug;608(7923):609-617.
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Immunity.
2022 Aug 9;55(8):1466-1482.e9.
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Cell.
2022 Aug 4;185(16):3008-3024.e16.
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