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Selecting a Unique Immunogen is Crucial in Antibody Design

Immunofluorescence of healthy iPSC-derived neurons labeled with Anti-NMDA Receptor, NR2B subunit (in green). Dr. Allison Ebert, Medical College of Wisconsin.

Our founder Mike Browning discusses the difficult road to the successful production of two of our best-selling NR2A and NR2B antibodies.

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View the 2A and 2B Antibodies

Read this great publication looking at the pre-synaptic mechanisms for synaptic deficits in Alzheimer’s disease models using 2 of our phosphospecific NMDA antibodies NR2B tyr1472 and NR2A tyr1325!

Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer’s disease

Zhang, L., Qin, Z., Sharmin, F., Lin, W., Ricke, K.M., Zasloff, M., Stewart, A.F. and Chen, H.H., 2021. Neurobiology of Disease, p.105402.

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Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180 kDa NR2A or NB2B subunit of the NMDAR respectively phosphorylated. Lanes 1/2 are labeled with NR2A Tyr1325 and Lanes 3/4 are labeled with NR2B Tyr1472. Phosphospecificity is shown in the second and fourth lane (+) where immunolabeling is completely eliminated by lysate treatment with lambda phosphatase (400 units/100uL lysate for 30 min).

See our NR2B tyr1472 Antibody

See our NR2A tyr1325 Antibody

What We’re Reading

Heatstroke’s Effect on the Brain

This summer has been a sizzler!! Have you ever wondered what happens to the brain during a heatstroke? Check out this article from Brain Facts describing how our body regulates the extreme heat of summer when outdoors.

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