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ADAM 15 Antibody
251996
0.1 mg
Brand
Abbiotec
Description
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) is a metalloproteinase with gelatinolytic and collagenolytic activity. ADAM 15 plays a role in the wound healing process, mediating both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. ADAM 15 inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. ADAM 15 suppresses cell motility towards fibronectin by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. ADAM 15 cleaves E-cadherin in response to growth factor deprivation.
Application
ELISAWB
Reactivity