Anti – Beclin – 1 (NT)

Brand

AnaSpec

Description

Autophagy, the process of bulk degradation of cellular proteins
through an autophagosomic-lysosomal pathway is important for
normal growth control and may be defective in tumor cells (1, 2).
Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the
yeast autophagy gene apg6 (3, 4), is a mammalian autophagy
gene that can inhibit tumorigenesis and is expressed at reduced
levels in human breast carcinoma, suggesting that defects in
autophagy proteins may contribute to the development or
progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit
Beclin-1-dependent autophagy in yeast and mammalian cells,
suggesting that Bcl-2 functions as an anti-autophagy protein as
well as an anti-apoptotic protein, which helps maintain autophagy
at levels that are more compatible with cell survival rather than
cell death (6).

Application

IHCWB

Reactivity

Photos