ANTI HUMAN RAR ALPHA

Brand

Iwai North America

Description

Retinoic acid receptor alpha (RARa; NR1B1) is closely related to TR. RARs bind to two retinoids, all-trans retinoic acid and 9-cis retinoic acid. RARa is expressed in adult skin, lung. RARa is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation and apoptosis, as well as homeostatic control. The specific chromosomal translocation found in acute promyelocytic leukemia (APL), fuses the RARa gene to a gene called promyelocytes (PML).

Application

WWB

Reactivity

Human

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