APECED Antibody

Brand

Abbiotec

Description

functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. APECED functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. Defects in APECED are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1). APECED is an autosomal recessive disease characterized by: (1) autoimmune polyendocrinopathies; (2) chronic mucocutaneous candidiasis; and (3) ectodermal dystrophies. In addition, a high proportion of patients develop squamous cell carcinoma of the oral mucosa. The disease is reported worldwide but is exceptionally prevalent among the Finnish population (incidence 1:25000) and the Iranian jews (incidence 1:9000).

Application

ELISA

Reactivity

Photos