AQP2 (Ser264) Antibody

Brand

Abbiotec

Description

Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Serine-264 has been identified as a phosphorylation site on AQP2 and shown to be regulated by vasopressin thus implicating this site as important in AQP2 trafficking and subcellular distribution.

Application

ELISA

Reactivity

BCanineChickenHuman

Photos