Catalog Number

250843

Unit

0.1 mg

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

The Bel-2 gene was isolated at the chromosonal breakpoint of t(14:18)-bearing follicular B cell lymphomas (1,2) Bel-2 bloacks cell death following a variety of stimuli and confers a death sparing effect to a certain hematopoieticcell lines following growth factor withdrawal ( 3, 5). Bel 2 appears to function in several subcellulart locations yet lacks any known motifs that would confer insight into its mechanism of action (6, 7). A morerecently identified protein, designated as Bax p21 ( i,e, Bel associated X protein) has exstensive amino acid homology with Bel-2 and both homodimerizes and forms heterodimers with Bel-2(8). Overexpression of Bax accelrates apoptotic death induced by cytokinedeprivation in an Il-3 dependent cell line and Bax also counters the death repressor activity of Bel-2 (8).

Product Citations

Recommended Products

Alternate Names

Accession No.

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human protein.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

Reacts with  :H | M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.