Proteins and PeptidesBiotinylated Influenza A [A/Guinea fowl/Hong Kong/WF10/99(H9N2)] Hemagglutinin (HA) Protein, Avitag™,His Tag

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HA1-V82E1

200ug

Brand

ACROBiosystems

Description

Source

Biotinylated Influenza A [A/Guinea fowl/Hong Kong/WF10/99(H9N2)] HA, Avitag,His Tag (HA1-V82E1) is expressed from human 293 cells (HEK293). It contains AA Asp 19 – Lys 523 (Accession # AAO46082.1).

 

Molecule : Hemagglutinin (HA)

 

Synonyms : HA,Hemagglutinin

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : AAO46082.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 60.0 kDa

 

Characteristics :

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 60.0 kDa. The protein migrates as 66-70 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Influenza, commonly known as “the flu”, is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.

 

References :

(1) Eccles, R., 2005, Lancet Infect Dis 5 (11): 718–25.
(2) Hui DS., 2008, Respirology. 13 Suppl 1: S10–3.
(3) Shadbolt, Peter. 2013, CNN. Retrieved 25 April 2013.
(4) The fight against bird flu. Nature 496 (7446): 397. April 24, 2013.
(5) Li, Q., et al., 2013, New England Journal of Medicine.

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