C7280948

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Description

C7280948 is a sulfone inhibitor of PRMT1 (IC50 values 12.75 μM and 26.7 μM for oligopeptide that contains the amino acids 1–21 of human histone H4 and non-histone protein Npl3 as methylation substrates respectively). PRMT inhibitors are potential drugs and interesting tools for cell biology. C7280948 is a useful tool in studying the epigenetic role of PRMT1. PRMT1 has been linked to the activation of estrogen and androgen receptors as well. PRMT1 is a necessary component for oncogenic transformation induced by a mixed lineage leukemia (MLL) complex, and therefore may represent a new treatment option for hormone-dependent cancer.

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