Canine GITR / TNFRSF18 Protein, His Tag

Source : 

Canine GITR, His Tag (GIR-C52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 23 – Pro 154 (Accession # D7F619-1).

Molecule : GITR

Synonyms : AITR,GITR,TNFRSF18,CD357

Format : Powder

Category : Immune Checkpoint Proteins

Accession : NP_001177673.1

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 15.8 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

References :

(1) Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
(2) Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.