CLOCK (8F7) Antibody
252994
0.1 ml
Brand
Abbiotec
Description
CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3′-CACGTG-5′) transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.
Application
WB
Reactivity
