Flumazenil
S1332
10mM/1mL~500mg
Brand
Selleckchem
Description
Flumazenil
Catalog No.S1332
Flumazenil is a benzodiazepine antagonist.
Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans. [1]
Clinical Trial Information( data from http://clinicaltrials.gov)
| NCT Number | Recruitment | Conditions | Sponsor /Collaborators |
Start Date | Phases |
|---|---|---|---|---|---|
| NCT02048969 | Not yet recruiting | Hepatic Encephalopathy|Liver Cirrhosis | Yale University | Phase 1|Phase 2 | |
| NCT01830881 | Completed | Pain|Anxiety|Nausea | Oregon Health and Science University | Phase 4 | |
| NCT01651520 | Recruiting | Multiple Sclerosis | Assistance Publique – H么pitaux de Paris | ||
| NCT01819675 | Recruiting | Stroke|Hemiplegia | Seoul National University Bundang Hospital|Ministry for Health, Welfare and Family Affairs, Korea | ||
| NCT01655914 | Recruiting | Insomnia | Coeruleus Ltd. | Phase 1 |
Chemical Information
| Molecular Weight (MW) | 303.29 |
|---|---|
| Formula |
C15H14FN3O3 |
| CAS No. | 78755-81-4 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in DMSO | |
| Syonnyms | Flumazepil, Ro 15-1788, Anexate, Lanexat, Mazicon, Roma |
| Solubility (25°C) * | In vitro | DMSO | 5 mg/mL (16 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Chemical Name | 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester |
|---|
Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.30329 | 3.0329 | – | – |
Application
Reactivity
