GDC-0980

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Description

GDC-0980 (RG7422) is a potent, highly selective, oral, dual inhibitor of class I PI3K and mTOR.GDC-0980 (RG7422) demonstrates broad preclinical activity in breast, ovarian, lung, and prostate cancer models.GDC-0980 (RG7422) can potently inhibit for isoforms of p110 including p110-alpha, p110-beta, p110-gamma and p110-delta. The IC50 value for inhibition of p110-alpha, p110-beta, p110-gamma and p110-delta by GDC-0980 is 5 nM,27 nM,7 nM and 14 nM. Besides the inhibition of Phosphoinositide 3-kinase, GDC-0980 also show strong inhibition to mTOR, which is a downstream target of akt but not only in PI3K signaling pathway. The Ki value for mTOR is 17 nM.

Application

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