Human ALK-7 Protein, His Tag

Source : 

Human ALK-7, His Tag (AL7-H52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 21 – Glu 113 (Accession # Q8NER5-1).

Molecule : ALK-7

Synonyms : ALK-7,ACTR-IC,ACVR1C

Format : Powder

Category : Bio-Markers & CD Antigens

Accession : NP_660302.2

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 11.9 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.9 kDa. The protein migrates as 15-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : 20 mM Tris, 150 mM NaCl, pH7.5

Description :

ALK-7 (Activin receptor-like kinase 7) is also known as Activin receptor type-1C, ACTR-IC, ACVR1C. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

References :

(1) Xu G, et al. 2004. J Clin Endocrinol Metab. 89(11):5523-34.
(2) Bondestam J, et al. 2001. Cytogenet Cell Genet. 95(3-4):157-62.