Human Brain Vascular Pericytes (HBVP)

Brand

iXCells

Description

Pericytes are contractile cells that wrap around the endothelial cells of capillary and venules throughout the body ^[1]. Pericytes are embedded in basement membrane, where they communicate with endothelial cells by means of direct physical contact and paracrine signaling ^[2]. In the brain, pericytes help sustain the blood-brain barriers, which regulate capillary blood flow, the clearance and phagocytosis of cellular debris and the permeability of the blood-brain barrier. Pericytes deficiency in the central nervous system can cause the blood-brain barrier breakdown, leading to neurodegenerative diseases.

iXCells Biotechnologies provides high quality Human Brain Vascular Pericytes (HBVP), which are isolated from human brain and cryopreserved at P2, with >0.5 million cells in each vial. These HBVP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for no more than 3 passages in Human Pericyte Growth Medium (Cat# MD-0030) under the condition suggested by iXCells Biotechnologies. Additional expansion is not recommended, because the purity of pericyte population may decrease.

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