Human CD2 / SRBC Protein, His Tag

Source : 

Human CD2, His Tag (CD2-H5226) is expressed from human 293 cells (HEK293). It contains AA Lys 25 – Asp 209 (Accession # AAH33583).

Molecule : CD2

Synonyms : CD2,SRBC,LFA-2,T11

Format : Powder

Category : Bio-Markers & CD Antigens

Accession : AAH33583

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 22.3 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.3 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

References :

(1) Wilkins A., et al., 2003, Curr Protein Pept Sci 4 (5): 367–73.
(2) Yang J., et al., 2001, Curr Protein Pept Sci 2 (1): 1–17.
(3) Bodian D.L., et al., 1994, Structure 2:755-766.