Human CD209 / DC-SIGN Protein, His Tag

Source : 

Human CD209, His Tag (CD9-H5246) is expressed from human 293 cells (HEK293). It contains AA Gln 59 – Ala 404 (Accession # Q9NNX6-1).

Molecule : CD209

Synonyms : DC-SIGN,CD209,DC-SIGN1,CLEC4L

Format : Powder

Category : Bio-Markers & CD Antigens

Accession : NP_066978.1

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 41.3 kDa

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

References :

(1) Geijtenbeek TB, et al. 2000. Nat Immunol. 1(4):353-7.
(2) Geijtenbeek TB, et al. 2000. Cell. 100(5):587-97.
(3) Engering A, et al. 2002. J Immunol. 168(5):2118-26.