Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells

ZZZZ_Status (Active, Disc) : Discontinued

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; p75NTR; CD271;

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Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=909

Description (Long Description) : 

Nerve growth factor (NGF) receptor, also known as p75NTR,  is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399 aa) consisting of a signal peptide (28 aa), an extracellular domain (222 aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 aa) and a cytoplasmic domain (155 aa).

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The NGF Receptor-Fc chimera consists of 25-45% carbohydrate by weight.

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