Human PCSK9 Propeptide & Rabbit Mature PCSK9 (154-686) Protein, His Tag

Source : 

Human PCSK9 Propeptide & Rabbit Mature PCSK9 (154-686), His Tag (PC9-R52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 31 – Gln 152 & Ser 154 – Ala 686 (Accession # Q8NBP7-1 (Human) & A0A5F9DJY7-1 (Rabbit)).

Molecule : PCSK9

Synonyms : PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9

Format : Powder

Category : Bio-Markers & CD Antigens

Accession : NP_777596.2 & N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 13.8 kDa and 58.0 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non covalent interactions and with a calculated

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

References :

(1) Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928–33.
(2) Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
(3) Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454–9.