Human Tissue-Type Plasminogen Activator (TPA) Activity ELISA Assay Kit

Brand

Eagle Biosciences

Description

Tissue-type Plasminogen Activator (tPA) is a member of the serine proteinase family.
tPA functions to lyse fibrin clots into soluble plasmin fragments. tPA is active in two
forms, single chain and two chain. The two-chain tPA is created via interaction with the
plasmin product cleaving the single chain. This two-chain form is regarded as the more
active form.
Both single chain and two-chain tPA are complexable with PAI-1. PAI-1 acts as an
inhibitor for tPA by binding to the tPA and thus stifling its ability to lyse fibrin. tPA can
serve as an indicator of both myocardial infarction for patients with impaired fibrinolytic
systems as well as a marker for type-II diabetes.

Application

Reactivity

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