IL-6 ELISA

Brand

ALPCO

Description

Human Interleukin 6 (IL-6) is a 184 amino acid polypeptide with potential O- and N-glycosylation
sites and a significant homology with G-CSF. It is produced by various cells, including T- and
B-cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells, astrocytes, bone
marrow stroma cells, and several tumor cells. IL-6 regulates the growth and differentiation of
various cell types with major activities on the immune system, hematopoiesis, and inflammation.
These multiple actions are integrated within a complex cytokine network, where several cytokines
induce (IL-1, TNF, PDGF, IFNs, etc.) or are induced by IL-6 and the final effects result from either
synergistic or antagonistic activities between IL-6 and the other cytokines (IL-1, IL-2, IL-3, IL-4,
IL-5, IFN-γ, GM-CSF, M-CSF, CSF, etc.). IL-6 induces final maturation of B-cells into antibody
producing cells and is a potent growth factor for myeloma/plasmacytoma cells. It (co-)stimulates
T-cell growth and cytotoxic T-cell differentiation. It promotes megakaryocyte development and
synergizes with other cytokines to stimulate multipotent hematopoietic progenitors. IL-6 is also a
major inducer of the acute phase reactions in response to inflammation or tissue injury. Along with
IL-1 and TNF, it induces the synthesis of acute phase proteins (APP) by hepatocytes, each
cytokine or combination of cytokines showing a preferential pattern of APP production. IL-6 also
interacts with the neuroendocrine system, e.g., by inducing ACTH production. Thus, IL-6 is a
pleiotropic cytokine with multiple endocrine, paracrine and possibly autocrine activities in various
tissues.

Application

Reactivity

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