Influenza A [A/Shanghai/2/2013(H7N9)] Hemagglutinin (HA) Protein, His Tag

Source : 

Influenza A [A/Shanghai/2/2013(H7N9)] HA, His Tag (HA9-V5227) is expressed from human 293 cells (HEK293). It contains AA Asp 19 – Gly 338, Leu 341 – Asp 523 (Accession # R4NN21-1).

Molecule : Hemagglutinin (HA)

Synonyms : HA,Hemagglutinin

Format : Powder

Category : Viral Proteins

Accession : AHF20558.1

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 56.7 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 56.7 kDa. The protein migrates as 63-75 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Influenza, commonly known as “the flu”, is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.

References :

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(3) Shadbolt, Peter. 2013, CNN. Retrieved 25 April 2013.
(4) The fight against bird flu. Nature 496 (7446): 397. April 24, 2013.
(5) Li, Q., et al., 2013, New England Journal of Medicine.