Linifanib (ABT-869)
A10025-5
5mg
Brand
AdooQ BioScience
Description
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
|
In vitro (25°C) |
DMSO |
75 mg/mL (199.78 mM) |
|
|
Water |
<1 mg/mL (<1 mM) |
|
|
Ethanol |
<1 mg/mL (<1 mM) |
|
In vivo |
30% PEG400/0.5% Tween80/5% propylene glycol |
30 mg/mL |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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|
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Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
|
0.1 mM |
26.64 mL |
133.19 mL |
266.38 mL |
|
0.5 mM |
5.33 mL |
26.64 mL |
53.28 mL |
|
1 mM |
2.66 mL |
13.32 mL |
26.64 mL |
|
5 mM |
0.53 mL |
2.66 mL |
5.33 mL |
*The above data is based on the productmolecular weight 375.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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CATALOG NUM |
A10025 |
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ACTIONS |
Inhibitor |
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M. WT |
375.4 |
|
FORMULA |
C21H18FN5O |
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SOLUBILITY |
DMSO |
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PURITY |
>98% |
|
STORAGE |
at -20°C 3 years Powder |
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CAS NO. |
796967-16-3 |
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SYNONYMS |
ABT869, ABT-869 |
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SMILES |
CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N |
Application
Reactivity
