Mercaptopurine (6-MP)
S1305
10mM/1mLã€50mg
Brand
Selleckchem
Description
Mercaptopurine (6-MP)
Catalog No.S1305
Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
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Biological Activity
| Description | Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. | |||||
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| Targets | ||||||
| IC50 | ||||||
| In vitro | Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2] | |||||
| In vivo | ||||||
| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
Download Mercaptopurine (6-MP) SDF
| Molecular Weight (MW) | 152.18 |
|---|---|
| Formula |
C5H4N4S |
| CAS No. | 50-44-2 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in DMSO | |
| Syonnyms | Purinethol, 6-mercaptopurine, 6-MP |
| Solubility (25°C) * | In vitro | DMSO | 30 mg/mL (197 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Chemical Name | 3H-purine-6(7H)-thione |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.15218 | 1.5218 | 3.0436 | 4.5654 |
Application
Reactivity
