Mitoxantrone
S1889
50mg~300mg
Brand
Selleckchem
Description
Mitoxantrone
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation. [1][2][3]
Chemical Information
| Molecular Weight (MW) | 444.48 |
|---|---|
| Formula |
C22H28N4O6 |
| CAS No. | 70476-82-3 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in DMSO | |
| Syonnyms | Novantrone |
| Solubility (25°C) * | In vitro | DMSO | 89 mg/mL (200 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.44448 | 4.4448 | 8.8896 | 13.3344 |
Application
Reactivity
