ML323

Brand

No Brand

Description

ML323 is a highly potent inhibitor of the USP1-UAF1 deubiquitinase complex with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases. ML323 potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells. ML323 and related N-benzyl-2-phenylpyrimidin-4-amine derivatives possess nanomolar USP1/UAF1 inhibitory potency.

Application

Reactivity

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