Monoclonal Antibody against 5 – Methylcytosine

Brand

AnaSpec

Description

5-Methylcytidine is a modified base found in DNA of
plants and vertebrates. DNA methylation is a postreplication
process involved in the establishment of
genomic imprinting, in the control of gene expression
and of differentiation. Carcinogenesis is associated
with alterations of the DNA methylation pattern: a
global DNA hypomethylation is often detected in
tumor tissues, associated with local hypermethylation
sites. This antibody has been developed to discriminate
between the modified base and its normal counterpart.
lt has been used to detect alterations in the urinary
excretion of nucleosides by cancer patients, to visualize
the distribution of methyl-rich regions along human
chromosomes, to quantify in situ differences between
normal and malignant cells from peripheral blood as well
as on tissue sections.

Application

Reactivity

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