N4-Hydroxycytidine (5 mg)

ZZZZ_Status (Active, Disc) : Active

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

β-D-N4-hydroxycytidine; NHC; CAS 3258-02-4

Antibody_Isotype
(Antibody only) :

Application_Details :

Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon RNA reduction in Huh7 cells; also is a novel inhibitor of CHIKV (Chikungunya virus), inhibits venezuelan equine encephalitis virus (VEEV) with EC50 of <1 uM (8-11).

Background_Info :

Clone_Name
(AB only, monoclonals) :

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1744

Description (Long Description) : 

Pharmacology: N4-Hydroxycytidine was originally identified as a mutagen effecting AT to GC base-pair transitions (1). It has also been found to have antiviral properties against a broad range of viruses including hepatitis C (2), norovirus (3), Ebola virus (4), influenza and respiratory syncytial viruses (5) and coronaviruses (6). Active molecule in the antiviral pro-drug clinical candidate EIDD-28017. PubChem CID: 197020.

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.

InChI
InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1

InChI Key
XCUAIINAJCDIPM-XVFCMESISA-N

Canonical SMILES
C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O

Isomeric SMILES
C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Expiry_Date : 

Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.

Format (Form) : 

Dry, white powder.

Immunogen (Antigen) :

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MSDS (File name) :