ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
β-D-N4-hydroxycytidine; NHC; CAS 3258-02-4
(Antibody only) :
Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon RNA reduction in Huh7 cells; also is a novel inhibitor of CHIKV (Chikungunya virus), inhibits venezuelan equine encephalitis virus (VEEV) with EC50 of <1 uM (8-11).
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1744
Description (Long Description) :
Pharmacology: N4-Hydroxycytidine was originally identified as a mutagen effecting AT to GC base-pair transitions (1). It has also been found to have antiviral properties against a broad range of viruses including hepatitis C (2), norovirus (3), Ebola virus (4), influenza and respiratory syncytial viruses (5) and coronaviruses (6). Active molecule in the antiviral pro-drug clinical candidate EIDD-28017. PubChem CID: 197020.
Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Format (Form) :
Dry, white powder.
Immunogen (Antigen) :
MSDS (File name) :