Chemical CompoundsNepicastat

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M3267

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Description

Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ±0.8 and 9.0 ±0.8 nM for bovine and human, respectively. Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.

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