ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
NTZ; CAS 55981-09-4
(Antibody only) :
NTZ demonstrates IC50 values of 2.5 and 10 uM for Giardia and Cryptosporidium, respectively. Additionally, NTZ kills replicating and nonreplicating M. tuberculosis with an IC50 value of 1 uM, while seemingly evading the development of resistance (6).
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1748
Description (Long Description) :
Pharmacology: Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double- stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin (5). PubChem CID: 41684.
Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Format (Form) :
Dry, white powder.
Immunogen (Antigen) :
MSDS (File name) :