Oxonic acid potassium salt

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Description

Oxonic acid was found to inhibit the phosphorylation of 5-FU to 5-fluorouridine-5′-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro. Oxonic acid potassium salt has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

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