Pimobendan

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Description

Pimobendan (Vetmedin) is a Ca (2+) sensitizer with an IC50 of 26 uM and a selective phosphodiesterase III inhibitor with an IC50 of <1 uM. The inhibitory effects of pimobendan on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Pimobendan decreased the catecholamine secretion (IC (50)=29.5 uM) elicited by carbachol, an agonist at nicotinic acetylcholine receptors, but not that elicited by veratridine, an activator of voltage-dependent Na (+) channels, or by high K (+), an activator of voltage-dependent Ca (2+) channels. Pimobendan also inhibited carbachol-induced influx of Na (+) (IC (50)=25.9 uM) and Ca (2+) (IC (50)=26.0 uM), but not veratridine-induced Na (+) influx or high K (+)-induced Ca (2+) influx.

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