Polyclonal antibody specific to RYR2 Phospho Serine-2808

Brand

Badrilla

Description

A fully validated, highly specific affinity purified rabbit polyclonal antibody to Serine-2814 phosphorylated Ryanodine Receptor (anti-RYR2 PS-2814)

The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of
Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction (Bers,
2002). CaMKII, was able to phosphorylate Ser-2814 of RYR2 (Wehrens et al., 2004) enhancing Ca2+
– sensitivity and increasing open
probability. Excessive phosphorylation of Ser-2814 leads to atrial fibrillation (Dobrer and wehsens, 2010), arrhythmias and sudden death
(Van Oort et al, 2010)

Application

Reactivity

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