Shank1 Antibody

Brand

Abbiotec

Description

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) is an adaptor protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, as well as in the actin based cytoskeleton. Shank1 plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Shank1 is expressed in the brain, particularly in the amygdala, hippocampus, substantia nigra and thalamus.

Application

ELISAWB

Reactivity

HumanMouse

Photos