STAT5B (5B3) Antibody

Brand

Abbiotec

Description

STAT5 (Signal transducer and activator of transcription 5A) carries out a dual function: signal transduction and activation of transcription. STAT5 is tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Phosphorylation results in translocation into the nucleus, where it binds to the GAS element and activates transcription. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.

Application

Reactivity

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