TNFRSF11B (5A11) Antibody

Brand

Abbiotec

Description

OPG (Osteoprotegerin) is a decoy receptor for RANKL by neutralizing its function in osteoclastogenesis. OPG inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. OPG is up-regulated by increasing calcium concentration and estrogens. Defects in OPG are the cause of juvenile Paget disease, which is characterized by rapid bone remodeling leading to deformities, fractures and osteopenia.

Application

WB

Reactivity

Photos