MoA Finder (Mode of Action) : Doxorubicin

Figure 1: Graphical presentation of the correlation of the drug sensitivity profile of doxorubicin to 732 reference compound‘s drug sensitivity profiles. Blue dots represent positive correlation and negative correlation represents red. X-axis: Spearman Rho correlation coefficient, Y axis: Spearman p-value

Biomarker Analysis:  Nutlin-3 

Figure 2: The graphical representation of nutlin-3 gene expression analysis using Limma test results shows highly expressed genes in drug-sensitive/resistant cell lines. MDM2 and other p53 pathway-related genes were highly expressed in tumor cell lines, which were sensitive to nutlin-3 treatment. Blue dots are genes with high expression associated with sensitivity, yellow dots are genes with high expression associated with resistance. X-Axis: Difference in gene expression between responding and non-responding tumor cell lines (log2); Y-Axis: Limma p-value.