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Organoids and Immortalized Cells
類器官（Organoids）是由幹細胞或器官前驅細胞（progenitor cells）在體外透過3D培養形成的微型組織。它們能模擬真實器官的結構與功能，是疾病模式、藥物篩選及再生醫學的重要工具。另一方面，永生化細胞（Immortalized cell lines）則是透過基因改造或病毒轉染，繞過細胞分裂限制，使其具備無限增殖能力的細胞。這些細胞系為生物研究提供了穩定且具可重複性的細胞來源。
近期的研究顯示，類器官技術已進步到能建造包含多種細胞類型、免疫成分及血管網絡的複雜系統。同時，永生化的人類 B 細胞在生產單株抗體方面展現了極高效率，並克服了異源性抗體所引發的免疫排斥問題。目前，永生化細胞正被用於開發更穩定且具規模化潛力的類器官模型。
Related Products
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Catalog |
Product Name |
Application |
Classification |
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WB, IHC |
Characterization of Cardiac Organoids |
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WB, ICC/IF, IHC, FC |
Characterization of Liver Organoids |
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ICC/IF,IHC, IP, FC |
Characterization of Intestinal Organoids |
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WB, ICC/IF, IHC |
Characterization of Brain Organoids |
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WB,ELISA,SDS-PAGE |
Culture of Lung Organoids |
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WB,ELISA,SDS-PAGE |
Culture of Liver Organoids |
References
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1.1.Mallapaty S. Mini hearts, lungs and livers made in lab now grow their own blood vessels. Nature. 2025;643(8073):892. doi:10.1038/d41586-025-02183-9 |
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2.Miao Y, Pek NM, Tan C, et al. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025;188(16):4295-4313.e27. doi:10.1016/j.cell.2025.05.041 |
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3.Garreta E, Moya-Rull D, Centeno A, et al. Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion. Nat Biomed Eng. Published online October 31, 2025. doi:10.1038/s41551-025-01542-1 |
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4.Xu H, Xiang X, Ding W, Dong W, Hu Y. The Research Progress on Immortalization of Human B Cells. Microorganisms. 2023;11(12):2936. Published 2023 Dec 7. doi:10.3390/microorganisms11122936 |
